The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKC-dependent inhibition of the AKT pathway

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Assad Kahn, Suzana; Lima Costa, Silvia; Gholamin, Sharareh; Nitta, Ryan T.; Dubois, Gustavo Luiz; Fève, Marie; Zeniou, Maria; Cerqueira Coelho, Paulo Lucas; El-Habr, Elias; Cadusseau, Josette; Varlet, Pascale; Mitra, Siddharta S.; Devaux, Bertrand; Kilhoffer, Marie-Claude; Cheshier, Samuel H.; Moura-Neto, Vivaldo; Haiech, Jacques; Junier, Marie-Pierre; Chneiweiss, Hervé;
  • Publisher: Wiley Open Access
  • Journal: EMBO Molecular Medicine, volume 8, issue 5, pages 511-526 (issn: 1757-4676, eissn: 1757-4684)
  • Publisher copyright policies & self-archiving
  • Identifiers: pmc: PMC5130115, doi: 10.15252/emmm.201505421
  • Subject: rottlerin | Research Article | Neuroscience | [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] | sh PKCδ | omega V1.1 | 1 | [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology | GL261 | [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology | δV1.1 | glioma | sh PKC | Cancer | sh PKC omega | V1 | Research Articles
    mesheuropmc: nervous system diseases | neoplasms

Published online; International audience; A variety of drugs targeting monoamine receptors are routinely used in human pharmacology. We assessed the effect of these drugs on the viability of tumor-initiating cells isolated from patients with glioblastoma. Among the drug... View more
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