Novel Kazal-type Protease inhibitors from the skin secretion of the Splendid leaf frog, Cruziohyla calcarifer

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Proaño Bolaños, Carolina; Li, Renjie; Zhou, Mei; Wang, Lei; Xi, Xinping; Tapia, Elicio E.; Coloma, Luis A.; Chen, Tianbao; Shaw, Chris;
(2017)
  • Publisher: Elsevier
  • Journal: volume 15,pages1-13issn: 2212-9685, eissn: 2212-9685
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/j.euprot.2017.02.001, pmc: PMC5965718
  • Subject: QH426-470 | Tandem mass spectrometry | Genetics | Kazal-type proteinase inhibitors | Peptidomic | Cruziohyla calcarifer | Regular Article | Molecular cloning | Kazal-type proteinase inhibitors; frog skin secretion; peptidomic; molecular cloning; tandem mass spectrometry; Cruziohyla calcarifer | Frog skin secretion

Peptidase inhibitors have an important role controlling a variety of biological processes. Here, we employed a peptidomic approach including molecular cloning, tandem mass spectrometry and enzymatic assays to reveal 7 Kazal-type proteinase inhibitors (CCKPs) (18 variant... View more
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