publication . Article . 2015

Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity

Shelton, Jonathan; Yun, Sujin; Losee Olson, Susan; Turek, Fred; Bonaventure, Pascal; Dvorak, Curt; Lovenberg, Timothy; Dugovic, Christine;
Open Access English
  • Published: 15 Jan 2015 Journal: Frontiers in Behavioral Neuroscience, volume 8 (issn: 1662-5153, eissn: 1662-5153, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Recent reports have illustrated a reciprocal relationship between circadian rhythm disruption and mood disorders. The 5-HT7 receptor may provide a crucial link between the two sides of this equation since the receptor plays a critical role in sleep, depression, and circadian rhythm regulation. To further define the role of the 5-HT7 receptor as a potential pharmacotherapy to correct circadian rhythm disruptions, the current study utilized the selective 5-HT7 antagonist JNJ-18038683 (10 mg/kg) in three different circadian paradigms. While JNJ-18038683 was ineffective at phase shifting the onset of wheel running activity in mice when administered at different c...
Subjects
free text keywords: phase shift, Serotonin, mood, Neurosciences. Biological psychiatry. Neuropsychiatry, Neuroscience, RC321-571, non-photic, Original Research Article, 5-HT7 receptor, photic, Depression, circadian rhythms
71 references, page 1 of 5

Adriani W. Travaglini D. Lacivita E. Saso L. Leopoldo M. Laviola G. (2012). Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice. Neuropharmacology 62, 833–842. 10.1016/j.neuropharm.2011.09.012 21945717 [PubMed] [DOI]

Antle M. C. Marchant E. G. Niel L. Mistlberger R. E. (1998). Serotonin antagonists do not attenuate activity-induced phase shifts of circadian rhythms in the Syrian hamster. Brain Res. 813, 139–149. 10.1016/s0006-8993(98)01048-8 9824687 [PubMed] [DOI]

Belenky M. A. Pickard G. E. (2001). Subcellular distribution of 5-HT(1B) and 5-HT(7) receptors in the mouse suprachiasmatic nucleus. J. Comp. Neurol. 432, 371–388. 10.1002/cne.1109 11246214 [PubMed] [DOI]

Benedetti F. Colombo C. Pontiggia A. Bernasconi A. Florita M. Smeraldi E. (2003). Morning light treatment hastens the antidepressant effect of citalopram: a placebo-controlled trial. J. Clin. Psychiatry 64, 648–653. 10.4088/jcp.v64n0605 12823078 [PubMed] [DOI]

Blier P. (2003). The pharmacology of putative early-onset antidepressant strategies. Eur. Neuropsychopharmacol. 13, 57–66. 10.1016/s0924-977x(02)00173-6 12650947 [PubMed] [DOI]

Bloch G. Herzog E. D. Levine J. D. Schwartz W. J. (2013). Socially synchronized circadian oscillators. Proc. Biol. Sci. 280:20130035. 10.1098/rspb.2013.0035 23825203 [OpenAIRE] [PubMed] [DOI]

Bonaventure P. Dugovic C. Kramer M. De Boer P. Singh J. Wilson S. . (2012). Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder. J. Pharmacol. Exp. Ther. 342, 429–440. 10.1124/jpet.112.193995 22570363 [PubMed] [DOI]

Bonaventure P. Kelly L. Aluisio L. Shelton J. Lord B. Galici R. . (2007). Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior and rapid eye movement sleep suppression induced by citalopram in rodents. J. Pharmacol. Exp. Ther. 321, 690–698. 10.1124/jpet.107.119404 17314195 [PubMed] [DOI]

Bonaventure P. Nepomuceno D. Kwok A. Chai W. Langlois X. Hen R. . (2002). Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice. J. Pharmacol. Exp. Ther. 302, 240–248. 10.1124/jpet.302.1.240 12065723 [PubMed] [DOI]

Ciarleglio C. M. Resuehr H. E. Mcmahon D. G. (2011). Interactions o f the serotonin and circadian systems: nature and nurture in rhythms and blues. Neuroscience 197, 8–16. 10.1016/j.neuroscience.2011.09.036 21963350 [PubMed] [DOI]

Cuesta M. Clesse D. Pévet P. Challet E. (2009). New light on the serotonergic paradox in the rat circadian system. J. Neurochem. 110, 231–243. 10.1111/j.1471-4159.2009.06128.x 19457131 [PubMed] [DOI]

Cuesta M. Mendoza J. Clesse D. Pevet P. Challet E. (2008). Serotonergic activation potentiates light resetting of the main circadian clock and alters clock gene expression in a diurnal rodent. Exp. Neurol. 210, 501–513. 10.1016/j.expneurol.2007.11.026 18190911 [PubMed] [DOI]

Daan S. Pittendrigh C. S. (1976). A functional analysis of circadian pacemakers in nocturnal rodents. J. Comp. Physiol. 106, 253–266. 10.1007/bf01417857 [OpenAIRE] [DOI]

Duncan M. J. Congleton M. R. (2010). Neural mechanisms mediating circadian phase resetting by activation of 5-HT(7) receptors in the dorsal raphe: roles of GABAergic and glutamatergic neurotransmission. Brain Res. 1366, 110–119. 10.1016/j.brainres.2010.09.103 20920493 [OpenAIRE] [PubMed] [DOI]

Duncan M. J. Davis V. A. (2005). Cyclic AMP mediates circadian phase shifts induced by microinjection of serotonergic drugs in the hamster dorsal raphe nucleus. Brain Res. 1058, 10–16. 10.1016/j.brainres.2005.07.016 16150426 [PubMed] [DOI]

71 references, page 1 of 5
Abstract
Recent reports have illustrated a reciprocal relationship between circadian rhythm disruption and mood disorders. The 5-HT7 receptor may provide a crucial link between the two sides of this equation since the receptor plays a critical role in sleep, depression, and circadian rhythm regulation. To further define the role of the 5-HT7 receptor as a potential pharmacotherapy to correct circadian rhythm disruptions, the current study utilized the selective 5-HT7 antagonist JNJ-18038683 (10 mg/kg) in three different circadian paradigms. While JNJ-18038683 was ineffective at phase shifting the onset of wheel running activity in mice when administered at different c...
Subjects
free text keywords: phase shift, Serotonin, mood, Neurosciences. Biological psychiatry. Neuropsychiatry, Neuroscience, RC321-571, non-photic, Original Research Article, 5-HT7 receptor, photic, Depression, circadian rhythms
71 references, page 1 of 5

Adriani W. Travaglini D. Lacivita E. Saso L. Leopoldo M. Laviola G. (2012). Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice. Neuropharmacology 62, 833–842. 10.1016/j.neuropharm.2011.09.012 21945717 [PubMed] [DOI]

Antle M. C. Marchant E. G. Niel L. Mistlberger R. E. (1998). Serotonin antagonists do not attenuate activity-induced phase shifts of circadian rhythms in the Syrian hamster. Brain Res. 813, 139–149. 10.1016/s0006-8993(98)01048-8 9824687 [PubMed] [DOI]

Belenky M. A. Pickard G. E. (2001). Subcellular distribution of 5-HT(1B) and 5-HT(7) receptors in the mouse suprachiasmatic nucleus. J. Comp. Neurol. 432, 371–388. 10.1002/cne.1109 11246214 [PubMed] [DOI]

Benedetti F. Colombo C. Pontiggia A. Bernasconi A. Florita M. Smeraldi E. (2003). Morning light treatment hastens the antidepressant effect of citalopram: a placebo-controlled trial. J. Clin. Psychiatry 64, 648–653. 10.4088/jcp.v64n0605 12823078 [PubMed] [DOI]

Blier P. (2003). The pharmacology of putative early-onset antidepressant strategies. Eur. Neuropsychopharmacol. 13, 57–66. 10.1016/s0924-977x(02)00173-6 12650947 [PubMed] [DOI]

Bloch G. Herzog E. D. Levine J. D. Schwartz W. J. (2013). Socially synchronized circadian oscillators. Proc. Biol. Sci. 280:20130035. 10.1098/rspb.2013.0035 23825203 [OpenAIRE] [PubMed] [DOI]

Bonaventure P. Dugovic C. Kramer M. De Boer P. Singh J. Wilson S. . (2012). Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder. J. Pharmacol. Exp. Ther. 342, 429–440. 10.1124/jpet.112.193995 22570363 [PubMed] [DOI]

Bonaventure P. Kelly L. Aluisio L. Shelton J. Lord B. Galici R. . (2007). Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior and rapid eye movement sleep suppression induced by citalopram in rodents. J. Pharmacol. Exp. Ther. 321, 690–698. 10.1124/jpet.107.119404 17314195 [PubMed] [DOI]

Bonaventure P. Nepomuceno D. Kwok A. Chai W. Langlois X. Hen R. . (2002). Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice. J. Pharmacol. Exp. Ther. 302, 240–248. 10.1124/jpet.302.1.240 12065723 [PubMed] [DOI]

Ciarleglio C. M. Resuehr H. E. Mcmahon D. G. (2011). Interactions o f the serotonin and circadian systems: nature and nurture in rhythms and blues. Neuroscience 197, 8–16. 10.1016/j.neuroscience.2011.09.036 21963350 [PubMed] [DOI]

Cuesta M. Clesse D. Pévet P. Challet E. (2009). New light on the serotonergic paradox in the rat circadian system. J. Neurochem. 110, 231–243. 10.1111/j.1471-4159.2009.06128.x 19457131 [PubMed] [DOI]

Cuesta M. Mendoza J. Clesse D. Pevet P. Challet E. (2008). Serotonergic activation potentiates light resetting of the main circadian clock and alters clock gene expression in a diurnal rodent. Exp. Neurol. 210, 501–513. 10.1016/j.expneurol.2007.11.026 18190911 [PubMed] [DOI]

Daan S. Pittendrigh C. S. (1976). A functional analysis of circadian pacemakers in nocturnal rodents. J. Comp. Physiol. 106, 253–266. 10.1007/bf01417857 [OpenAIRE] [DOI]

Duncan M. J. Congleton M. R. (2010). Neural mechanisms mediating circadian phase resetting by activation of 5-HT(7) receptors in the dorsal raphe: roles of GABAergic and glutamatergic neurotransmission. Brain Res. 1366, 110–119. 10.1016/j.brainres.2010.09.103 20920493 [OpenAIRE] [PubMed] [DOI]

Duncan M. J. Davis V. A. (2005). Cyclic AMP mediates circadian phase shifts induced by microinjection of serotonergic drugs in the hamster dorsal raphe nucleus. Brain Res. 1058, 10–16. 10.1016/j.brainres.2005.07.016 16150426 [PubMed] [DOI]

71 references, page 1 of 5
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publication . Article . 2015

Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity

Shelton, Jonathan; Yun, Sujin; Losee Olson, Susan; Turek, Fred; Bonaventure, Pascal; Dvorak, Curt; Lovenberg, Timothy; Dugovic, Christine;