A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

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Tukachinsky, Hanna; Lopez, Lyle V.; Salic, Adrian;
  • Publisher: The Rockefeller University Press
  • Journal: The Journal of Cell Biology,volume 191,issue 2,pages415-428 (issn: 0021-9525, eissn: 1540-8140)
  • Related identifiers: doi: 10.1083/jcb.201004108, pmc: PMC2958481
  • Subject: Research Articles | Article

In vertebrates, Hedgehog (Hh) signaling initiated in primary cilia activates the membrane protein Smoothened (Smo) and leads to activation of Gli proteins, the transcriptional effectors of the pathway. In the absence of signaling, Gli proteins are inhibited by the cytop... View more
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