A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues

Article English OPEN
Sarah A. Hibbert; Rachel E.B. Watson; Neil K. Gibbs; Patrick Costello; Clair Baldock; Anthony S. Weiss; Christopher E.M. Griffiths; Michael J. Sherratt;
(2015)
  • Publisher: Elsevier BV
  • Journal: Redox Biology, volume 5, pages 101-113 (issn: 2213-2317, eissn: 2213-2317)
  • Publisher copyright policies & self-archiving
  • Identifiers: pmc: PMC4412910, doi: 10.1016/j.redox.2015.04.003
  • Subject: Sunscreen | SSR, solar simulated radiation | R5-920 | LTBP, latent transforming growth factor β-binding protein | UVR, ultraviolet radiation. | MED, minimal erythemal dose | QH301-705.5 | UVA radiation | Chromophores | ECM, extracellular matrix | ROS, reactive oxygen species | Medicine (General) | Solar simulated radiation | Photoageing | AFM, atomic force microscopy | Photodecomposition | HDF, human dermal fibroblast | TGFβ, transforming growth factor β | Research Paper | Biology (General) | MMP, matrix metalloproteinase
    mesheuropmc: integumentary system

Excessive ultraviolet radiation (UVR) exposure of the skin is associated with adverse clinical outcomes. Although both exogenous sunscreens and endogenous tissue components (including melanins and tryptophan-derived compounds) reduce UVR penetration, the role of endogen... View more
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