MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation.

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Zhuo Wang ; Stephanie Brandt ; Alexandra Medeiros ; Soujuan Wang ; Hao Wu ; Alexander Dent ; C Henrique Serezani
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 10, issue 2 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0115855, pmc: PMC4338261
  • Subject: Q | R | Research Article | Science | Medicine

Macrophages dictate both initiation and resolution of inflammation. During acute inflammation classically activated macrophages (M1) predominate, and during the resolution phase alternative macrophages (M2) are dominant. The molecular mechanisms involved in macrophage p... View more