MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation.
C Henrique Serezani
- Publisher: Public Library of Science (PLoS)
(issn: 1932-6203, eissn: 1932-6203)
Q | R | Research Article | Science | Medicine
Macrophages dictate both initiation and resolution of inflammation. During acute inflammation classically activated macrophages (M1) predominate, and during the resolution phase alternative macrophages (M2) are dominant. The molecular mechanisms involved in macrophage p...