Applications of Nanotechnology in Dermatology

Article, Other literature type English OPEN
DeLouise, Lisa A. (2012)
  • Publisher: Elsevier BV
  • Journal: Journal of Investigative Dermatology, volume 132, issue 3, pages 964-975 (issn: 0022-202X)
  • Related identifiers: doi: 10.1038/jid.2011.425
  • Subject: Molecular Biology | Cell Biology | Dermatology | Biochemistry | Article
    mesheuropmc: integumentary system

What are nanoparticles and why are they important in dermatology? These questions are addressed by highlighting recent developments in the nanotechnology field that have increased the potential for intentional and unintended nanoparticle skin exposure. The role of environmental factors in the interaction of nanoparticles with skin and the potential mechanisms by which nanoparticles may influence skin response to environmental factors are discussed. Trends emerging from recent literature suggest that the positive benefit of engineered nanoparticles for use in cosmetics and as tools for understanding skin biology and curing skin disease, out weigh potential toxicity concerns. Discoveries reported in this journal are highlighted. This review begins with a general introduction to the field of nanotechnology and nanomedicine. This is followed by a discussion of the current state of understanding of nanoparticle skin penetration and their use in three different therapeutic applications. Challenges that must be overcome to derive clinical benefit from the application of nanotechnology to skin are discussed last, providing perspective on the significant opportunity that exists for future studies in investigative dermatology.
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