FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis

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Kelley, M; Yochem, J; Krieg, M; Calixto, A; Heiman, MG; Kuzmanov, A; Meli, V; Chalfie, M; Goodman, MB; Shaham, S; Frand, A; Fay, DS; (2015)
  • Publisher: eScholarship, University of California
  • Journal: volume 4issn: 2050-084X, eissn: 2050-084X
  • Related identifiers: pmc: PMC4395870, doi: 10.7554/eLife.06565., doi: 10.7554/eLife.06565
  • Subject: Developmental Biology and Stem Cells | C. elegans | extra cellular matrix | morphogenesis | Research Article | Cell Biology | mec-8 | splicing | fibrillin | epidermis

eLife digest For an animal embryo to develop, its cells must organize themselves into tissues and organs. For example, skin and the lining of internal organs—such as the lungs and gut—are made from cells called epithelial cells, which are tightly linked to form flat she... View more