publication . Article . 2014

Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2

Yasunori Shintani; Hannes CA Drexler; Hidetaka Kioka; Cesare MN Terracciano; Steven R Coppen; Hiromi Imamura; Masaharu Akao; Junichi Nakai; Ann P Wheeler; Shuichiro Higo; ...
Open Access English
  • Published: 07 Mar 2014
  • Publisher: EMBO Press
  • Country: United Kingdom
Abstract
Toll-like receptor 9 (TLR9) has a key role in the recognition of pathogen DNA in the context of infection and cellular DNA that is released from damaged cells. Pro-inflammatory TLR9 signalling pathways in immune cells have been well investigated, but we have recently discovered an alternative pathway in which TLR9 temporarily reduces energy substrates to induce cellular protection from stress in cardiomyocytes and neurons. However, the mechanism by which TLR9 stimulation reduces energy substrates remained unknown. Here, we identify the calcium-transporting ATPase, SERCA2 (also known as Atp2a2), as a key molecule for the alternative TLR9 signalling pathway. TLR9 ...
Subjects
Medical Subject Headings: chemical and pharmacologic phenomena
free text keywords: Adenosine Triphosphate, Animals, Calcium, Calcium Signaling, Cells, Cultured, Endoplasmic Reticulum, Fibroblasts, Mice, Mitochondria, Myocytes, Cardiac, Protein Binding, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Stress, Physiological, Toll-Like Receptor 9, 0601 Biochemistry and Cell Biology, Developmental Biology, Scientific Reports, danger signal, DNA, SERCA2, TLR9, Genetics, Biochemistry, Molecular Biology, Alternative complement pathway, Biology, ATPase, biology.protein, ATP synthase, Mitochondrion, Receptor, Cell biology, Immune system
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