User of ordered mixtures to obtain high dose homogeneity in mini-tablets : studies of orally disintegrating systems for children

Master thesis English OPEN
Løding, Fredrik Sandberg; (2011)
  • Publisher: University of Tromsø
  • Subject: FAR-3901 | VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Biofarmasi: 736 | VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Biopharmacy: 736

Studies have shown that homogeneity is higher in ordered mixtures compared to random mixtures. Based on this ordered mixtures should be particularly suitable for the preparation of mini-tablets. The overall aim of the study was to compare the homogeneity of ordered ... View more
  • References (29)
    29 references, page 1 of 3

    10 11 12 12 12 13 14 14 16 17 18 18 18 19 19 20 21 22 23 3. Materials and methods

    3.1 Materials

    3.2 Particle characterisation of raw materials 3.2.1 Sieving analysis 3.2.2 Fractionation of powder samples 3.2.2 Particle size analysis by laser diffraction 3.2.3 Microscopy 3.2.4 Scanning electron microscopy 3.2.5 Apparent particle density 3.2.6 External surface area 3.2.7 Estimation of diameter on micronized particles from external surface area 3.2.8 Bulk and tapped density 3.2.9 Powder flow rate and Angle of repose

    3.3 Preparation of powder mixtures 3.3.1 Conventional mixture 3.3.2 Ordered mixture

    3.4 Powder mixture characterization 3.4.1 Homogeneity 3.4.2 Surface coverage of micronized particles on the carrier 3.4.3 Scanning electron microscopy

    3.5 The compaction of mini-tablets 3.5.1 Addition of lubricant 3.5.2 Manual filling of dies 3.5.3 Compaction of mini-tablets

    3.6 Characterisation of mini-tablets 3.6.1 Mass variation 3.6.2 Friability testing 3.6.3 Crushing strength 3.6.4 Simulated wetting test 3.6.5 Quantification of active and dose variation in mini-tablets

    Table 14. Characteristics of mini-tablets Particle Mass single size mini-tablet fraction [mg] × [μm]

    ABDELBARY, G., PRINDERRE, P., EOUANI, C., JOACHIM, J., REYNIER, J. P. & PICCERELLE, P. 2004. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. International Journal of Pharmaceutics, 278, 423-433.

    ALDERBORN, G., DUBERG, M. & NYSTROM, C. 1985. Studies on direct compression of tablets. X. Measurement of tablet surface area by permeametry. Powder Technol., 41, 49-56.

  • Metrics
    No metrics available
Share - Bookmark