Cu(II) Complexes of Isoniazid Schiff Bases: DNA/BSA Binding and Cytotoxicity Studies on A549 Cell Line

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Ramadevi, Pulipaka; Singh, Rinky; Prajapati, Akhilesh; Gupta, Sarita; Chakraborty, Debjani;
  • Publisher: Hindawi Publishing Corporation
  • Journal: Advances in Chemistry (issn: 2356-6612, eissn: 2314-7571)
  • Related identifiers: doi: 10.1155/2014/630575
  • Subject: Chemistry | QD1-999 | Article Subject

A series of isonicotinoyl hydrazones have been synthesized via template method and were complexed to Cu(II). The ligands are coordinated to Cu(II) ion through the enolic oxygen and azomethine nitrogen resulting in a square planar geometry. The CT-DNA and bovine serum al... View more
  • References (58)
    58 references, page 1 of 6

    Kamel, M. M., Ali, H. I., Anwar, M. M., Mohameda, N. A., Soliman, M.. Synthesis, antitumor activity and molecular docking study of novel sulfonamide-Schiff's bases, thiazolidinones, benzothiazinones and their C-nucleoside derivatives. European Journal of Medicinal Chemistry. 2010; 45 (2): 572-580

    Creaven, B. S., Duff, B., Egan, D. A., Kavanagh, K., Rosair, G., Thangella, V. R., Walsh, M.. Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases. Inorganica Chimica Acta. 2010; 363 (14): 4048-4058

    Green, D. R., Reed, J. C.. Mitochondria and apoptosis. Science. 1998; 281 (5381): 1309-1312

    Ma, Y., Cao, L., Kavabata, T., Yoshino, T., Yang, B. B., Okada, S.. Cupric nitrilotriacetate induces oxidative DNA damage and apoptosis in human leukemia HL-60 cells. Free Radical Biology and Medicine. 1998; 25 (4-5): 568-575

    Liang, F., Wu, C., Lin, H., Li, T., Gao, D., Li, Z., Wei, J., Zheng, C., Sun, M.. Copper complex of hydroxyl-substituted triazamacrocyclic ligand and its antitumor activity. Bioorganic and Medicinal Chemistry Letters. 2003; 13: 2469-2472

    Hegg, E. L., Burstyn, J. N.. Toward the development of metal-based synthetic nucleases and peptidases: a rationale and progress report in applying the principles of coordination chemistry. Coordination Chemistry Reviews. 1998; 173 (1): 133-165

    Kannan, D., Arumugham, M. N.. Synthesis, characterisation, DNA-binding studies and antimicrobial activity of copper(II) complex with 1,10 phenanthroline, L-tyrosine and thiourea as ligands. International Journal of Research in Controlled Release. 2012; 2: 10

    Dhar, S., Senapati, D., Das, P. K., Chattopadhyay, P., Nethaji, M., Chakravarty, A. R.. Ternary copper complexes for photocleavage of DNA by red light: direct evidence for sulfur-to-copper charge transfer and d-d band involvement. Journal of the American Chemical Society. 2003; 125 (40): 12118-12124

    Dhar, S., Reddy, P. A. N., Nethaji, M., Mahadevan, S., Saha, M. K., Chakravarty, A. R.. Effect of steric encumbrance of tris(3-phenylpyrazolyl)borate on the structure and properties of ternary copper(II) complexes having N,N-donor heterocyclic bases. Inorganic Chemistry. 2002; 41 (13): 3469-3476

    Chakravarty, A. R., Reddy, P. A. N., Santra, B. K., Thomas, A. M.. Copper complexes as chemical nucleases. Journal of Chemical Sciences—Indian Academy of Sciences. 2002; 114: 391-401

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