Proteomics Mapping of Cord Blood Identifies Haptoglobin “Switch-On” Pattern as Biomarker of Early-Onset Neonatal Sepsis in Preterm Newborns

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Buhimschi, Catalin S.; Bhandari, Vineet; Dulay, Antonette T.; Nayeri, Unzila A.; Abdel-Razeq, Sonya S.; Pettker, Christian M.; Thung, Stephen; Zhao, Guomao; Han, Yiping W.; Bizzarro, Matthew; Buhimschi, Irina A.;
(2011)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 6,issue 10 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC3189953, doi: 10.1371/journal.pone.0026111
  • Subject: Computational Biology | Immunomodulation | Research Article | Molecular Cell Biology | Modeling | Diagnostic Medicine | Pathology | Infectious Diseases | Blood Chemistry | Epidemiology | Genetics | Neonatalology | Pregnancy Complications | Molecular Genetics | Global Health | Cellular Types | Biology | Proteomics | Biomarkers | Clinical Research Design | Pregnancy | Blood Cells | Preterm Labor | Medicine | Critical Care and Emergency Medicine | Infectious Disease Modeling | Genetic Epidemiology | Q | R | Population Biology | Clinical Immunology | Science | Biochemistry | Obstetrics and Gynecology | Pediatrics | General Pathology | Gene Expression | Sepsis

Background Intra-amniotic infection and/or inflammation (IAI) are important causes of preterm birth and early-onset neonatal sepsis (EONS). A prompt and accurate diagnosis of EONS is critical for improved neonatal outcomes. We sought to explore the cord blood proteome a... View more
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