Induction of mesenchymal stem cell chondrogenesis by polyacrylate substrates

Article English OPEN
Glennon-Alty, Laurence; Williams, Rachel; Dixon, Simon; Murray, Patricia;
  • Publisher: Elsevier BV
  • Journal: Acta Biomaterialia,volume 9,issue 4,pages6,041-6,051 (issn: 1742-7061, eissn: 1878-7568)
  • Related identifiers: pmc: PMC3594746, doi: 10.1016/j.actbio.2012.12.007
  • Subject: Molecular Biology | Mesenchymal stem cell | Biotechnology | Chondrocyte | Surface chemistry | Cell culture | Biomedical Engineering | Biochemistry | Biomaterials | Article | Polyacrylate

Mesenchymal stem cells (MSCs) can generate chondrocytes in vitro, but typically need to be cultured as aggregates in the presence of transforming growth factor beta (TGF-β), which makes scale-up difficult. Here we investigated if polyacrylate substrates modelled on the ... View more
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