The damaging effects of short chain fatty acids on Escherichia coli membranes

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Royce, Liam A.; Liu, Ping; Stebbins, Matthew J.; Hanson, Benjamin C.; Jarboe, Laura R.;
  • Publisher: Springer Nature
  • Journal: Applied Microbiology and Biotechnology,volume 97,issue 18,pages8,317-8,327 (issn: 0175-7598, eissn: 1432-0614)
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  • Related identifiers: pmc: PMC3757260, doi: 10.1007/s00253-013-5113-5
  • Subject: Applied Microbial and Cell Physiology | Membrane lipids | Escherichia coli | Biotechnology | Applied Microbiology and Biotechnology | Short chain fatty acids | Tolerance | Bacterial inhibition | Membrane fluidity

Carboxylic acids are an attractive biorenewable chemical. However, like many other fermentatively produced compounds, they are inhibitory to the biocatalyst. An understanding of the mechanism of toxicity can aid in mitigating this problem. Here, we show that hexanoic an... View more
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