Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma

Article English OPEN
Hettmer, Simone; Schinzel, Anna C; Tchessalova, Daria; Schneider, Michaela; Parker, Christina L; Bronson, Roderick T; Richards, Nigel GJ; Hahn, William C; Wagers, Amy J; (2015)
  • Publisher: eLife Sciences Publications, Ltd
  • Journal: volume 4issn: 2050-084X, eissn: 2050-084X
  • Related identifiers: pmc: PMC4695385, doi: 10.7554/eLife.09436, doi: 10.7554/eLife.09436.
  • Subject: Developmental Biology and Stem Cells | Mouse | Cell Biology | Research Article | sarcoma | QD | asparaginase | asparagine synthetase | functional genomics | rhabdomyosarcoma | Human

eLife digest Sarcoma is a type of cancer that forms in the connective tissues of the body, such as bone, cartilage, muscle and fat. Usually, treatment involves surgical removal of the tumor and/or radiation to kill the tumor cells. However, if sarcomas spread to other p... View more
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