publication . Other literature type . Article . 2004

Identification of sparsely distributed clusters of cis-regulatory elements in sets of co-expressed genes

Kreiman, Gabriel;
Open Access English
  • Published: 01 Jan 2004
  • Publisher: Oxford University Press (OUP)
Abstract
Sequence information and high-throughput methods to measure gene expression levels open the door to explore transcriptional regulation using computational tools. Combinatorial regulation and sparseness of regulatory elements throughout the genome allow organisms to control the spatial and temporal patterns of gene expression. Here we study the organization of cis-regulatory elements in sets of co-regulated genes. We build an algorithm to search for combinations of transcription factor binding sites that are enriched in a set of potentially co-regulated genes with respect to the whole genome. No knowledge is assumed about involvement of specific sets of transcrip...
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publication . Other literature type . Article . 2004

Identification of sparsely distributed clusters of cis-regulatory elements in sets of co-expressed genes

Kreiman, Gabriel;