publication . Article . 2012

Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection

J Nunes; M Naymark; L Sauer; A Muhammad; H Keun; J Sturge; J Stebbing; J Waxman; D Pchejetski;
Open Access English
  • Published: 28 Feb 2012 Journal: British Journal of Cancer, volume 106, issue 5, pages 909-915 (issn: 0007-0920, eissn: 1532-1827, Copyright policy)
  • Publisher: Nature Publishing Group
  • Country: United Kingdom
Abstract
Background: Current markers available for screening normal populations and for monitoring prostate cancer (PCa) treatment lack sensitivity and selectivity. Sphingosine-1-phosphate (S1P) is a circulating lipid second messenger involved in cell growth and migration, the immune response, angiogenesis, and malignant transformation. Methods: Eighty-eight patients with localised, locally advanced, or metastatic PCa were recruited into this prospective single-centre study. Plasma S1P levels were measured and compared with age-matched controls with benign prostate hyperplasia (BPH) (n=110) or with young healthy males with the very small chance of having PCa foci (n=20)....
Subjects
free text keywords: Molecular Diagnostics, prostate cancer, molecular marker, diagnosis, prognosis, sphingosine-1-phosphate, anaemia, Science & Technology, Life Sciences & Biomedicine, Oncology, BREAST-CANCER, CELL, 1-PHOSPHATE, INHIBITION, EXPRESSION, DISEASE, MODELS, GROWTH, BLOOD, MEN, Anemia, Biomarkers, Tumor, Cell Line, Tumor, Disease Progression, Early Detection of Cancer, Erythrocytes, Humans, Lysophospholipids, Male, Phosphotransferases (Alcohol Group Acceptor), Prostate-Specific Antigen, Prostatic Neoplasms, Sphingosine, 1112 Oncology And Carcinogenesis, Oncology & Carcinogenesis, Cancer Research, chemistry.chemical_compound, chemistry, Pathology, medicine.medical_specialty, medicine, Sphingosine kinase 1, biology.protein, biology, medicine.disease, Biomarker (medicine), Immunology, business.industry, business
Related Organizations
32 references, page 1 of 3

American Cancer Society. 2011

Bielawski, J, Szulc, ZM, Hannun, YA, Bielawska, A. Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods. 2006; 39: 82-91 [OpenAIRE] [PubMed]

Bonhoure, E, Pchejetski, D, Aouali, N, Morjani, H, Levade, T, Kohama, T, Cuvillier, O. Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia. 2006; 20: 95-102 [PubMed]

Camerer, E, Regard, JB, Cornelissen, I, Srinivasan, Y, Duong, DN, Palmer, D, Pham, TH, Wong, JS, Pappu, R, Coughlin, SR. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest. 2009; 119: 1871-1879 [OpenAIRE] [PubMed]

Deutschman, DH, Carstens, JS, Klepper, RL, Smith, WS, Page, MT, Young, TR, Gleason, LA, Nakajima, N, Sabbadini, RA. Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. Am Heart J. 2003; 146: 62-68 [PubMed]

Eberhard, M, Ferlinz, K, Alizzi, K, Cacciato, PM, Faggio, C, Foller, M, Lang, F. FTY720-induced suicidal erythrocyte death. Cell Physiol Biochem. 2010; 26: 761-766 [OpenAIRE] [PubMed]

Edsall, LC, Spiegel, S. Enzymatic measurement of sphingosine 1-phosphate. Anal Biochem. 1999; 272: 80-86 [OpenAIRE] [PubMed]

Fox, TE, Bewley, MC, Unrath, KA, Pedersen, MM, Anderson, RE, Jung, DY, Jefferson, LS, Kim, JK, Bronson, SK, Flanagan, JM, Kester, M. Circulating sphingolipid biomarkers in models of type 1 diabetes. J Lipid Res. 2011; 52: 509-517 [OpenAIRE] [PubMed]

Garcia, JG, Liu, F, Verin, AD, Birukova, A, Dechert, MA, Gerthoffer, WT, Bamberg, JR, English, D. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest. 2001; 108: 689-701 [OpenAIRE] [PubMed]

Hanel, P, Andreani, P, Graler, MH. Erythrocytes store and release sphingosine 1-phosphate in blood. FASEB J. 2007; 21: 1202-1209 [PubMed]

Henry, NL, Pchejetski, D, A'Hern, R, Nguyen, AT, Charles, P, Waxman, J, Li, L, Storniolo, AM, Hayes, DF, Flockhart, DA, Stearns, V, Stebbing, J. Inflammatory cytokines and aromatase inhibitor-associated musculoskeletal syndrome: a case-control study. Br J Cancer. 2010; 103: 291-296 [OpenAIRE] [PubMed]

Iversen, P, Rasmussen, F, Christensen, IJ. Serum testosterone as a prognostic factor in patients with advanced prostatic carcinoma. Scand J Urol Nephrol. 1994; 157: 41-47

Kawamori, T, Osta, W, Johnson, KR, Pettus, BJ, Bielawski, J, Tanaka, T, Wargovich, MJ, Reddy, BS, Hannun, YA, Obeid, LM, Zhou, D. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J. 2006; 20: 386-388 [PubMed]

Licht, T, Tsirulnikov, L, Reuveni, H, Yarnitzky, T, Ben-Sasson, SA. Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3). Blood. 2003; 102: 2099-2107 [OpenAIRE] [PubMed]

Lin, DW. Beyond PSA: utility of novel tumor markers in the setting of elevated PSA. Urol Oncol. 2009; 27: 315-321 [PubMed]

32 references, page 1 of 3
Abstract
Background: Current markers available for screening normal populations and for monitoring prostate cancer (PCa) treatment lack sensitivity and selectivity. Sphingosine-1-phosphate (S1P) is a circulating lipid second messenger involved in cell growth and migration, the immune response, angiogenesis, and malignant transformation. Methods: Eighty-eight patients with localised, locally advanced, or metastatic PCa were recruited into this prospective single-centre study. Plasma S1P levels were measured and compared with age-matched controls with benign prostate hyperplasia (BPH) (n=110) or with young healthy males with the very small chance of having PCa foci (n=20)....
Subjects
free text keywords: Molecular Diagnostics, prostate cancer, molecular marker, diagnosis, prognosis, sphingosine-1-phosphate, anaemia, Science & Technology, Life Sciences & Biomedicine, Oncology, BREAST-CANCER, CELL, 1-PHOSPHATE, INHIBITION, EXPRESSION, DISEASE, MODELS, GROWTH, BLOOD, MEN, Anemia, Biomarkers, Tumor, Cell Line, Tumor, Disease Progression, Early Detection of Cancer, Erythrocytes, Humans, Lysophospholipids, Male, Phosphotransferases (Alcohol Group Acceptor), Prostate-Specific Antigen, Prostatic Neoplasms, Sphingosine, 1112 Oncology And Carcinogenesis, Oncology & Carcinogenesis, Cancer Research, chemistry.chemical_compound, chemistry, Pathology, medicine.medical_specialty, medicine, Sphingosine kinase 1, biology.protein, biology, medicine.disease, Biomarker (medicine), Immunology, business.industry, business
Related Organizations
32 references, page 1 of 3

American Cancer Society. 2011

Bielawski, J, Szulc, ZM, Hannun, YA, Bielawska, A. Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods. 2006; 39: 82-91 [OpenAIRE] [PubMed]

Bonhoure, E, Pchejetski, D, Aouali, N, Morjani, H, Levade, T, Kohama, T, Cuvillier, O. Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia. 2006; 20: 95-102 [PubMed]

Camerer, E, Regard, JB, Cornelissen, I, Srinivasan, Y, Duong, DN, Palmer, D, Pham, TH, Wong, JS, Pappu, R, Coughlin, SR. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest. 2009; 119: 1871-1879 [OpenAIRE] [PubMed]

Deutschman, DH, Carstens, JS, Klepper, RL, Smith, WS, Page, MT, Young, TR, Gleason, LA, Nakajima, N, Sabbadini, RA. Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. Am Heart J. 2003; 146: 62-68 [PubMed]

Eberhard, M, Ferlinz, K, Alizzi, K, Cacciato, PM, Faggio, C, Foller, M, Lang, F. FTY720-induced suicidal erythrocyte death. Cell Physiol Biochem. 2010; 26: 761-766 [OpenAIRE] [PubMed]

Edsall, LC, Spiegel, S. Enzymatic measurement of sphingosine 1-phosphate. Anal Biochem. 1999; 272: 80-86 [OpenAIRE] [PubMed]

Fox, TE, Bewley, MC, Unrath, KA, Pedersen, MM, Anderson, RE, Jung, DY, Jefferson, LS, Kim, JK, Bronson, SK, Flanagan, JM, Kester, M. Circulating sphingolipid biomarkers in models of type 1 diabetes. J Lipid Res. 2011; 52: 509-517 [OpenAIRE] [PubMed]

Garcia, JG, Liu, F, Verin, AD, Birukova, A, Dechert, MA, Gerthoffer, WT, Bamberg, JR, English, D. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest. 2001; 108: 689-701 [OpenAIRE] [PubMed]

Hanel, P, Andreani, P, Graler, MH. Erythrocytes store and release sphingosine 1-phosphate in blood. FASEB J. 2007; 21: 1202-1209 [PubMed]

Henry, NL, Pchejetski, D, A'Hern, R, Nguyen, AT, Charles, P, Waxman, J, Li, L, Storniolo, AM, Hayes, DF, Flockhart, DA, Stearns, V, Stebbing, J. Inflammatory cytokines and aromatase inhibitor-associated musculoskeletal syndrome: a case-control study. Br J Cancer. 2010; 103: 291-296 [OpenAIRE] [PubMed]

Iversen, P, Rasmussen, F, Christensen, IJ. Serum testosterone as a prognostic factor in patients with advanced prostatic carcinoma. Scand J Urol Nephrol. 1994; 157: 41-47

Kawamori, T, Osta, W, Johnson, KR, Pettus, BJ, Bielawski, J, Tanaka, T, Wargovich, MJ, Reddy, BS, Hannun, YA, Obeid, LM, Zhou, D. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J. 2006; 20: 386-388 [PubMed]

Licht, T, Tsirulnikov, L, Reuveni, H, Yarnitzky, T, Ben-Sasson, SA. Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3). Blood. 2003; 102: 2099-2107 [OpenAIRE] [PubMed]

Lin, DW. Beyond PSA: utility of novel tumor markers in the setting of elevated PSA. Urol Oncol. 2009; 27: 315-321 [PubMed]

32 references, page 1 of 3
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publication . Article . 2012

Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection

J Nunes; M Naymark; L Sauer; A Muhammad; H Keun; J Sturge; J Stebbing; J Waxman; D Pchejetski;