publication . Article . Other literature type . 2017

Intrathymic injection of hematopoietic progenitor cells establishes functional T cell development in a mouse model of severe combined immunodeficiency

Marcel R.M. van den Brink; Andrea Z. Tuckett; Richard J. O'Reilly; Johannes L. Zakrzewski; Raymond H. Thornton;
Open Access English
  • Published: 16 May 2017 Journal: Journal of Hematology & Oncology, volume 10 (eissn: 1756-8722, Copyright policy)
  • Publisher: BioMed Central
Abstract
Background Even though hematopoietic stem cell transplantation can be curative in patients with severe combined immunodeficiency, there is a need for additional strategies boosting T cell immunity in individuals suffering from genetic disorders of lymphoid development. Here we show that image-guided intrathymic injection of hematopoietic stem and progenitor cells in NOD-scid IL2rγnull mice is feasible and facilitates the generation of functional T cells conferring protective immunity. Methods Hematopoietic stem and progenitor cells were isolated from the bone marrow of healthy C57BL/6 mice (wild-type, Luciferase+, CD45.1+) and injected intravenously or intrathym...
Subjects
free text keywords: Research, SCID, NSG mouse, Thymus, Cell therapy, Hematopoietic stem cell, Cancer Research, Oncology, Molecular Biology, Hematology, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Hematopoietic stem cell transplantation, medicine.medical_treatment, medicine, T cell, medicine.anatomical_structure, Immunology, Progenitor cell, Interleukin 3, CXCR4, Severe combined immunodeficiency, medicine.disease, Biology
Related Organizations
Funded by
NIH| Mucosal Immunity and Microbiota in Intestinal Graft-versus-Host Disease
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 9R01AI100288-06A1
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| The role of autophagy gene Atg16L1 in allogeneic hematopoietic stem cell transplantation - Resubmission - 1
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01HL123340-01A1
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| Strategies to enhance thymus-independent T cell development in cancer patients
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1K08CA160659-01
  • Funding stream: NATIONAL CANCER INSTITUTE
,
EC| THYMISTEM
Project
THYMISTEM
Development of Stem Cell Based Therapy for Thymic Regeneration
  • Funder: European Commission (EC)
  • Project Code: 602587
  • Funding stream: FP7 | SP1 | HEALTH
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