Newly Identified CYP2C93 Is a Functional Enzyme in Rhesus Monkey, but Not in Cynomolgus Monkey

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Yasuhiro Uno; Shotaro Uehara; Sakae Kohara; Kazuhide Iwasaki; Ryoichi Nagata; Koichiro Fukuzaki; Masahiro Utoh; Norie Murayama; Hiroshi Yamazaki;
(2011)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 6,issue 2 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3035658, doi: 10.1371/journal.pone.0016923
  • Subject: Oxygen Metabolism | Computational Biology | Genomic Medicine | Animal Models | Research Article | Oxidoreductases | Genetic Mutation | Enzymes | Gene Identification and Analysis | Functional Genomics | Mutagenesis | Genetics | Mutation Types | Drug Metabolism | Gene Splicing | Pharmacokinetics | Genomics | Sequence Analysis | Enzyme Classes | Molecular Genetics | Macaque | Biology | Veterinary Science | Enzyme Metabolism | Medicine | Gene Function | Drug Research and Development | Comparative Genomics | Q | R | Pharmacogenomics | Model Organisms | Drugs and Devices | Isozymes | Genetic Testing | Science | Biochemistry | Metabolism | Pharmacogenetics | Veterinary Pharmacology

Cynomolgus monkey and rhesus monkey are used in drug metabolism studies due to their evolutionary closeness and physiological resemblance to human. In cynomolgus monkey, we previously identified cytochrome P450 (P450 or CYP) 2C76 that does not have a human ortholog and ... View more
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