Changes in transcriptional orientation are associated with increases in evolutionary rates of enterobacterial genes

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Lin, Chieh-Hua; Lian, Chun-Yi; Hsiung, Chao Agnes; Chen, Feng-Chi;
(2011)
  • Publisher: BioMed Central
  • Journal: BMC Bioinformatics,volume 12,issue Suppl 9,pagesS19-S19 (issn: 1471-2105, eissn: 1471-2105)
  • Related identifiers: pmc: PMC3283321, doi: 10.1186/1471-2105-12-S9-S19
  • Subject: Molecular Biology | Biochemistry | Computer Science Applications | Proceedings

Background Changes in transcriptional orientation (“CTOs”) occur frequently in prokaryotic genomes. Such changes usually result from genomic inversions, which may cause a conflict between the directions of replication and transcription and an increase in mutation rate. ... View more
  • References (31)
    31 references, page 1 of 4

    1. Mackiewicz P, Mackiewicz D, Kowalczuk M, Cebrat S: Flip-flop around the origin and terminus of replication in prokaryotic genomes. Genome Biol 2001, 2(12):INTERACTIONS1004.

    2. Eisen JA, Heidelberg JF, White O, Salzberg SL: Evidence for symmetric chromosomal inversions around the replication origin in bacteria. Genome Biol 2000, 1(6):RESEARCH0011.

    3. Srivatsan A, Tehranchi A, MacAlpine DM, Wang JD: Co-orientation of replication and transcription preserves genome integrity. PLoS Genet 2010, 6(1):e1000810.

    4. Tillier ER, Collins RA: Replication orientation affects the rate and direction of bacterial gene evolution. J Mol Evol 2000, 51(5):459-463.

    5. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, ColladoVides J, Glasner JD, Rode CK, Mayhew GF, et al: The complete genome sequence of Escherichia coli K-12. Science 1997, 277(5331):1453-1462.

    6. McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, et al: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature 2001, 413(6858):852-856.

    7. Drummond DA, Wilke CO: Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution. Cell 2008, 134(2):341-352.

    8. Jordan IK, Rogozin IB, Wolf YI, Koonin EV: Essential genes are more evolutionarily conserved than are nonessential genes in bacteria. Genome Res 2002, 12(6):962-968.

    9. Sharp PM, Emery LR, Zeng K: Forces that influence the evolution of codon bias. Philos Trans R Soc Lond B Biol Sci 2010, 365(1544):1203-1212.

    10. Mira A, Ochman H: Gene location and bacterial sequence divergence. Mol Biol Evol 2002, 19(8):1350-1358.

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