Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development

Article, Other literature type English OPEN
Beucher, Anthony ; Martín, Mercè ; Spenle, Caroline ; Poulet, Martine ; Collin, Caitlin ; Gradwohl, Gérard (2012)
  • Publisher: Elsevier BV
  • Journal: Developmental Biology, volume 361, issue 2, pages 277-285 (issn: 0012-1606)
  • Related identifiers: doi: 10.1016/j.ydbio.2011.10.025, pmc: PMC3251922
  • Subject: Molecular Biology | Cell Biology | Developmental Biology | Article
    mesheuropmc: endocrine system

During mouse pancreas development, the transient expression of Neurogenin3 (Neurog3) in uncommitted pancreas progenitors is required to determine endocrine destiny. However it has been reported that Neurog3-expressing cells can eventually adopt acinar or ductal fates an... View more
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