publication . Article . 2000

Cation substitution in cationic phosphonolipids: A new concept to improve transfection activity and decrease cellular toxicity

Floch, V.; Loisel, S.; Guenin, E.; Herve, A.C.; Clement, J.C.; Yaouanc, J.J.; DES ABBAYES, H.; Ferec, C.;
Open Access English
  • Published: 01 Jan 2000
  • Publisher: American Chemical Society
Abstract
International audience; Cationic lipids have been shown to be an interesting alternative to viral vector-mediated gene delivery into in vitro and in vivo model applications. Prior studies have demonstrated that even minor structural modifications of the lipid hydrophobic domain or of the lipid polar domain result in significant changes in gene delivery efficiency. Previously, we developed a novel class of cationic lipids called cationic phosphonolipids and described the ability of these vectors to transfer DNA into different cell lines and in vivo. Up until now, in all new cationic lipids, nitrogen atoms have always carried the cationic or polycationic charge. R...
Subjects
free text keywords: [CHIM]Chemical Sciences
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publication . Article . 2000

Cation substitution in cationic phosphonolipids: A new concept to improve transfection activity and decrease cellular toxicity

Floch, V.; Loisel, S.; Guenin, E.; Herve, A.C.; Clement, J.C.; Yaouanc, J.J.; DES ABBAYES, H.; Ferec, C.;