A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target.

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Saur, Taixiang; DeMarco, Sarah E.; Ortiz, Angelica; Sliwoski, Gregory R.; Hao, Limin; Wang, Xin; Cohen, Bruce Michael; Buttner, Edgar (Ned) A.;

Author Summary Clozapine is the most effective medication for treatment-refractory schizophrenia but produces toxic side effects such as agranulocytosis, metabolic syndrome, and developmental defects after exposure early in life. However, clozapine's molecular mechanism... View more
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