ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation

Article English OPEN
Williams, Michelle M.; Vaught, David B.; Joly, Meghan Morrison; Hicks, Donna J.; Sanchez, Violeta; Owens, Philip; Rahman, Bushra; Elion, David L.; Balko, Justin M.; Cook, Rebecca S.;
  • Publisher: BioMed Central
  • Journal: Breast Cancer Research : BCR,volume 19 (issn: 1465-5411, eissn: 1465-542X)
  • Related identifiers: pmc: PMC5591538, doi: 10.1186/s13058-017-0893-7
  • Subject: Mammary gland development | PI3 kinase | ErbB3 | Research Article | ErbB4 | Prolactin | Lactation | Alveolar mammary epithelial cell | Akt | STAT5A | Jak2

Background During pregnancy, as the mammary gland prepares for synthesis and delivery of milk to newborns, a luminal mammary epithelial cell (MEC) subpopulation proliferates rapidly in response to systemic hormonal cues that activate STAT5A. While the receptor tyrosine ... View more