ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation

Article English OPEN
Michelle M. Williams; David B. Vaught; Meghan Morrison Joly; Donna J. Hicks; Violeta Sanchez; Philip Owens; Bushra Rahman; David L. Elion; Justin M. Balko; Rebecca S. Cook;
  • Publisher: BioMed Central
  • Journal: Breast Cancer Research : BCR,volume 19 (issn: 1465-5411, eissn: 1465-542X)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5591538, doi: 10.1186/s13058-017-0893-7
  • Subject: PI3 kinase | ErbB3 | ErbB4 | Research Article | Prolactin | Alveolar mammary epithelial cell | Akt | STAT5A | Jak2 | Neoplasms. Tumors. Oncology. Including cancer and carcinogens | Mammary gland development | Lactation | RC254-282

Background During pregnancy, as the mammary gland prepares for synthesis and delivery of milk to newborns, a luminal mammary epithelial cell (MEC) subpopulation proliferates rapidly in response to systemic hormonal cues that activate STAT5A. While the receptor tyrosine ... View more