ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation

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Michelle M. Williams; David B. Vaught; Meghan Morrison Joly; Donna J. Hicks; Violeta Sanchez; Philip Owens; Bushra Rahman; David L. Elion; Justin M. Balko; Rebecca S. Cook;

Background During pregnancy, as the mammary gland prepares for synthesis and delivery of milk to newborns, a luminal mammary epithelial cell (MEC) subpopulation proliferates rapidly in response to systemic hormonal cues that activate STAT5A. While the receptor tyrosine ... View more