DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution.
Article, Other literature type
Poon, Steven S S
Chavez, Elizabeth A
Sanders, Ashley D
Lansdorp, Peter M
- Publisher: NATURE PUBLISHING GROUP
DNA rearrangements such as sister chromatid exchanges (SCEs) are sensitive indicators of genomic stress and instability, but they are typically masked by single-cell sequencing techniques. We developed Strand-seq to independently sequence parental DNA template strands f...