DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution.

Article, Other literature type English OPEN
Falconer, Ester ; Hills, Mark ; Naumann, Ulrike ; Poon, Steven S S ; Chavez, Elizabeth A ; Sanders, Ashley D ; Zhao, Yongjun ; Hirst, Martin ; Lansdorp, Peter M (2012)

DNA rearrangements such as sister chromatid exchanges (SCEs) are sensitive indicators of genomic stress and instability, but they are typically masked by single-cell sequencing techniques. We developed Strand-seq to independently sequence parental DNA template strands f... View more
Share - Bookmark