publication . Article . 2013

Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis

Jonckers, Elisabeth; Vanhoutte, Greetje; Shah, Disha; Linden, Annemie; Delgado Y Palacios, Rafael; D Souza, Dany V.; Bigot, Christian; Verhoye, Marleen; Praet, Jelle;
Open Access
  • Published: 01 Jan 2013 Journal: volume 8, issue 12issn: 1932-6203, eissn: 1932-6203, Copyright policy
  • Publisher: Public Library of Science
Abstract
Abstract: Introduction: Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer's disease (AD). AD is a complex disorder, characterised by several pathological features. The problem with FC studies in patients is that it is not straightforward to focus on a specific aspect of pathology. In the current study, resting state functional magnetic resonance imaging (rsfMRI) is applied in a mouse model of amyloidosis to assess the effects of amyloid pathology on FC in the mouse brain. Methods: Nine APP/PS1 transgenic and nine wild-type mice (average age 18.9 months) were imaged on a 7T M...
Subjects
mesheuropmc: mental disorders
free text keywords: Q, R, Engineering sciences. Technology, Research Article, Science, Medicine
Funded by
EC| NAD
Project
NAD
NANOPARTICLES FOR THERAPY AND DIAGNOSIS OF ALZHEIMER DISEASE
  • Funder: European Commission (EC)
  • Project Code: 212043
  • Funding stream: FP7 | SP1 | NMP
,
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
37 references, page 1 of 3

1 Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT (2011) Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med 1: a006189 PubMed: 22229116.22229116 [OpenAIRE] [PubMed]

2 Johnson KA, Fox NC, Sperling RA, Klunk WE (2012) Brain imaging in Alzheimer disease. Cold Spring Harb Perspect Med 2: a006213 PubMed: 22474610.22474610 [OpenAIRE] [PubMed]

3 Clark VH, Resnick SM, Doshi J, Beason-Held LL, Zhou Y et al. (2012) Longitudinal imaging pattern analysis (SPARE-CD index) detects early structu ral and functional changes before cognitive decline in healthy older adults. Neurobiol Aging 33: 2733-2745. doi:10.1016/j.neurobiolaging.2012.01.010. PubMed: 22365049.22365049 [OpenAIRE] [PubMed]

4 van den Heuvel MP, Hulshoff Pol HE (2010) Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol 20: 519-534. doi:10.1016/S0924-977X(10)70776-8. PubMed: 20471808.20471808 [PubMed]

5 Biswal B, Yetkin FZ, Haughton VM, Hyde JS (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34: 537-541. doi:10.1002/mrm.1 910340409. PubMed: 8524021.8524021 [PubMed]

6 Wurina, Zang YF, Zhao SG (2012) Resting-state fMRI studies in epilepsy. Neurosci Bull 28: 449-455. doi:10.1007/s12264-012-1255-1. PubMed: 22833042.22833042 [OpenAIRE] [PubMed]

7 Filippi M, Rocca MA (2012) New magnetic resonance imaging biomarkers for the diagnosis of multiple sclerosis. Expert Opin Med Diagn 6: 109-120. doi:10.1517/17530059.2012.657624. PubMed: 23480654.23480654 [PubMed]

8 Sheline YI, Raichle ME (2013) Resting State Functional Connectivity in Preclinical. Journal of Alzheimer'S Disease - Biol Psychiatry . [OpenAIRE]

9 Hutchison RM, Leung LS, Mirsattari SM, Gati JS, Menon RS et al. (2011) Resting-state networks in the macaque at 7 T. NeuroImage 56: 1546-1555. doi:10.1016/j.neuroimage.2011.02.063. PubMed: 21356313.21356313 [PubMed]

10 Hutchison RM, Mirsattari SM, Jones CK, Gati JS, Leung LS (2010) Functional networks in the anesthetized rat brain revealed by independent component analysis of resting-state FMRI. J Neurophysiol 103: 3398-3406. doi:10.1152/jn.00141.2010. PubMed: 20410359.20410359 [PubMed]

11 Jonckers E, Van AJ, De VG, Van der Linden A, Verhoye M (2011) Functional connectivity fMRI of the rodent brain: comparison of functional connectivity networks in rat and mouse. PLOS ONE 6: e18876. doi:10.1371/journal.pone.0018876. PubMed: 21533116.21533116 [OpenAIRE] [PubMed]

12 Pawela CP, Biswal BB, Cho YR, Kao DS, Li R et al. (2008) Resting-state functional connectivity of the rat brain. Magn Reson Med 59: 1021-1029. doi:10.1002/mrm.21524. PubMed: 18429028.18429028 [OpenAIRE] [PubMed]

13 Bero AW, Bauer AQ, Stewart FR, White BR, Cirrito JR et al. (2012) Bidirectional relationship between functional connectivity and amyloid-beta deposition in mouse brain. J Neurosci 32: 4334-4340. doi:10.1523/JNEUROSCI.5845-11.2012. PubMed: 22457485.22457485 [OpenAIRE] [PubMed]

14 White BR, Bauer AQ, Snyder AZ, Schlaggar BL, Lee JM et al. (2011) Imaging of functional connectivity in the mouse brain. PLOS ONE 6: e16322. doi:10.1371/journal.pone.0016322. PubMed: 21283729.21283729 [OpenAIRE] [PubMed]

15 Little DM, Foxely S, Lazarov O (2012) A preliminary study targeting neuronal pathways activated following environmental enrichment by resting state functional magnetic resonance imaging. J Alzheimers Dis 32: 101-107. PubMed: 22766734.22766734 [OpenAIRE] [PubMed]

37 references, page 1 of 3
Abstract
Abstract: Introduction: Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer's disease (AD). AD is a complex disorder, characterised by several pathological features. The problem with FC studies in patients is that it is not straightforward to focus on a specific aspect of pathology. In the current study, resting state functional magnetic resonance imaging (rsfMRI) is applied in a mouse model of amyloidosis to assess the effects of amyloid pathology on FC in the mouse brain. Methods: Nine APP/PS1 transgenic and nine wild-type mice (average age 18.9 months) were imaged on a 7T M...
Subjects
mesheuropmc: mental disorders
free text keywords: Q, R, Engineering sciences. Technology, Research Article, Science, Medicine
Funded by
EC| NAD
Project
NAD
NANOPARTICLES FOR THERAPY AND DIAGNOSIS OF ALZHEIMER DISEASE
  • Funder: European Commission (EC)
  • Project Code: 212043
  • Funding stream: FP7 | SP1 | NMP
,
EC| INMIND
Project
INMIND
Imaging of Neuroinflammation in Neurodegenerative Diseases
  • Funder: European Commission (EC)
  • Project Code: 278850
  • Funding stream: FP7 | SP1 | HEALTH
37 references, page 1 of 3

1 Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT (2011) Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med 1: a006189 PubMed: 22229116.22229116 [OpenAIRE] [PubMed]

2 Johnson KA, Fox NC, Sperling RA, Klunk WE (2012) Brain imaging in Alzheimer disease. Cold Spring Harb Perspect Med 2: a006213 PubMed: 22474610.22474610 [OpenAIRE] [PubMed]

3 Clark VH, Resnick SM, Doshi J, Beason-Held LL, Zhou Y et al. (2012) Longitudinal imaging pattern analysis (SPARE-CD index) detects early structu ral and functional changes before cognitive decline in healthy older adults. Neurobiol Aging 33: 2733-2745. doi:10.1016/j.neurobiolaging.2012.01.010. PubMed: 22365049.22365049 [OpenAIRE] [PubMed]

4 van den Heuvel MP, Hulshoff Pol HE (2010) Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol 20: 519-534. doi:10.1016/S0924-977X(10)70776-8. PubMed: 20471808.20471808 [PubMed]

5 Biswal B, Yetkin FZ, Haughton VM, Hyde JS (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34: 537-541. doi:10.1002/mrm.1 910340409. PubMed: 8524021.8524021 [PubMed]

6 Wurina, Zang YF, Zhao SG (2012) Resting-state fMRI studies in epilepsy. Neurosci Bull 28: 449-455. doi:10.1007/s12264-012-1255-1. PubMed: 22833042.22833042 [OpenAIRE] [PubMed]

7 Filippi M, Rocca MA (2012) New magnetic resonance imaging biomarkers for the diagnosis of multiple sclerosis. Expert Opin Med Diagn 6: 109-120. doi:10.1517/17530059.2012.657624. PubMed: 23480654.23480654 [PubMed]

8 Sheline YI, Raichle ME (2013) Resting State Functional Connectivity in Preclinical. Journal of Alzheimer'S Disease - Biol Psychiatry . [OpenAIRE]

9 Hutchison RM, Leung LS, Mirsattari SM, Gati JS, Menon RS et al. (2011) Resting-state networks in the macaque at 7 T. NeuroImage 56: 1546-1555. doi:10.1016/j.neuroimage.2011.02.063. PubMed: 21356313.21356313 [PubMed]

10 Hutchison RM, Mirsattari SM, Jones CK, Gati JS, Leung LS (2010) Functional networks in the anesthetized rat brain revealed by independent component analysis of resting-state FMRI. J Neurophysiol 103: 3398-3406. doi:10.1152/jn.00141.2010. PubMed: 20410359.20410359 [PubMed]

11 Jonckers E, Van AJ, De VG, Van der Linden A, Verhoye M (2011) Functional connectivity fMRI of the rodent brain: comparison of functional connectivity networks in rat and mouse. PLOS ONE 6: e18876. doi:10.1371/journal.pone.0018876. PubMed: 21533116.21533116 [OpenAIRE] [PubMed]

12 Pawela CP, Biswal BB, Cho YR, Kao DS, Li R et al. (2008) Resting-state functional connectivity of the rat brain. Magn Reson Med 59: 1021-1029. doi:10.1002/mrm.21524. PubMed: 18429028.18429028 [OpenAIRE] [PubMed]

13 Bero AW, Bauer AQ, Stewart FR, White BR, Cirrito JR et al. (2012) Bidirectional relationship between functional connectivity and amyloid-beta deposition in mouse brain. J Neurosci 32: 4334-4340. doi:10.1523/JNEUROSCI.5845-11.2012. PubMed: 22457485.22457485 [OpenAIRE] [PubMed]

14 White BR, Bauer AQ, Snyder AZ, Schlaggar BL, Lee JM et al. (2011) Imaging of functional connectivity in the mouse brain. PLOS ONE 6: e16322. doi:10.1371/journal.pone.0016322. PubMed: 21283729.21283729 [OpenAIRE] [PubMed]

15 Little DM, Foxely S, Lazarov O (2012) A preliminary study targeting neuronal pathways activated following environmental enrichment by resting state functional magnetic resonance imaging. J Alzheimers Dis 32: 101-107. PubMed: 22766734.22766734 [OpenAIRE] [PubMed]

37 references, page 1 of 3
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publication . Article . 2013

Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis

Jonckers, Elisabeth; Vanhoutte, Greetje; Shah, Disha; Linden, Annemie; Delgado Y Palacios, Rafael; D Souza, Dany V.; Bigot, Christian; Verhoye, Marleen; Praet, Jelle;