In Vitro Selection of Single-Stranded DNA Molecular Recognition Elements against S. aureus Alpha Toxin and Sensitive Detection in Human Serum

Other literature type, Article English OPEN
Ka L. Hong; Luisa Battistella; Alysia D. Salva; Ryan M. Williams; Letha J. Sooter;
(2015)
  • Publisher: MDPI AG
  • Journal: International Journal of Molecular Sciences,volume 16,issue 2,pages2,794-2,809 (issn: 1422-0067, eissn: 1422-0067)
  • Related identifiers: doi: 10.3390/ijms16022794, pmc: PMC4346865
  • Subject: Chemistry | <i> in vitro</i> selection | QD1-999 | SELEX | molecular recognition element (MRE) | Article | QH301-705.5 | ELISA | <i>Staphylococcus aureus</i> | aptamer | in vitro selection | alpha toxin | ssDNA | Biology (General) | Staphylococcus aureus

Alpha toxin is one of the major virulence factors secreted by Staphylococcus aureus, a bacterium that is responsible for a wide variety of infections in both community and hospital settings. Due to the prevalence of S. aureus related infections and the emergence of meth... View more
  • References (48)
    48 references, page 1 of 5

    Bhakdi, S.; Tranum-Jensen, J. Alpha-toxin of Staphylococcus aureus. Microbiol. Rev. 1991, 55, 733-751.

    Lowy, F.D. Staphylococcus aureus infections. N. Engl. J. Med. 1998, 339, 520-532.

    Mediavilla, J.R.; Chen, L.; Uhlemann, A.C.; Hanson, B.M.; Rosenthal, M.; Stanak, K.; Koll, B.; Fries, B.C.; Armellino, D.; Schilling, M.E.; et al. Methicillin-susceptible Staphylococcus aureus ST398, New York and New Jersey, USA. Emerg. Infect. Dis. 2012, 18, 700-702.

    Emerg. Infect. Dis. 2003, 9, 978-984.

    Moet, G.J.; Jones, R.N.; Biedenbach, D.J.; Stilwell, M.G.; Fritsche, T.R. Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: Report from the SENTRY Antimicrobial Surveillance Program (1998-2004). Diagn. Microbiol. Infect. Dis.

    6. Stephens, J.M.; Gao, X.; Patel, D.A.; Verheggen, B.G.; Shelbaya, A.; Haider, S. Economic burden of inpatient and outpatient antibiotic treatment for methicillin-resistant Staphylococcus aureus complicated skin and soft-tissue infections: A comparison of linezolid, vancomycin, and daptomycin. Clinicoecon. Outcomes Res. 2013, 5, 447-457.

    7. Vandenesch, F.; Lina, G.; Henry, T. Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: A redundant arsenal of membrane-damaging virulence factors? Front. Cell. Infect. Microbiol. 2012, 2, 12.

    8. Jacobsson, G.; Colque-Navarro, P.; Gustafsson, E.; Andersson, R.; Mollby, R. Antibody responses in patients with invasive Staphylococcus aureus infections. Eur. J. Clin. Microbiol. Infect. Dis. 2010, 29, 715-725.

    9. Bubeck Wardenburg, J.; Patel, R.J.; Schneewind, O. Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia. Infect. Immun. 2007, 75, 1040-1044.

    10. Callegan, M.C.; Engel, L.S.; Hill, J.M.; O'Callaghan, R.J. Corneal virulence of Staphylococcus aureus: Roles of alpha-toxin and protein A in pathogenesis. Infect. Immun. 1994, 62, 2478-2482.

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