Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation

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Langer, Diana; Martianov, Igor; Alpern, Daniel; Rhinn, Muriel; Keime, Celine; Dolle, Pascal; Mengus, Gabrielle; Davidson, Irwin;

TAF4 (TATA-binding protein-associated factor 4) and its paralogue TAF4b are components of the TFIID core module. We inactivated the murine Taf4a gene to address Taf4 function during embryogenesis. Here we show that Taf4a(-/-) embryos survive until E9.5 where primary ger... View more
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