Peripheral surgical wounding may induce cognitive impairment through interlukin-6-dependent mechanisms in aged mice

Article English OPEN
Dong, Yuanlin ; Xu, Zhipeng ; Huang, Lining ; Zhang, Yiying ; Xie, Zhongcong (2016)
  • Publisher: Medknow Publications & Media Pvt Ltd
  • Journal: Medical Gas Research, volume 6, issue 4, pages 180-186 (issn: 2045-9912, eissn: 2045-9912)
  • Related identifiers: doi: 10.4103/2045-9912.196899., doi: 10.4103/2045-9912.196899, pmc: PMC5223308
  • Subject: Original Article | cognition | fear conditioning system | peripheral surgical wounding; interlukin-6; cognition; mice; fear conditioning system; neuroinflammation | Anesthesiology | peripheral surgical wounding | neuroinflammation | mice | RD78.3-87.3 | interlukin-6

Post-operative cognitive dysfunction (POCD) is associated with morbidity, mortality and increased cost of medical care. However, the neuropathogenesis and targeted interventions of POCD remain largely to be determined. We have found that the peripheral surgical wounding... View more