publication . Research . Article . 1996

Ex Vivo Spleen and Kidney Absorption of Xenoreactive Natural Antibodies Decreases Severity of Hyperacute Rejection in Pig-to-dog Renal Xenotransplantation

Nitta, Kohsaku;
Open Access English
  • Published: 01 Dec 1996 Journal: Hiroshima Journal of Medical Sciences, volume 45, issue 4, pages 119-125 (issn: 0018-2052, Copyright policy)
  • Publisher: Hiroshima University Medical Press
Abstract
The severe hyperacute rejection in pig-to-dog renal xenotransplantation is mainly caused by xenoreactive natural antibodies (NAb). Organ absorption (ex vivo perfusion of spleen and kidney of donor species) was performed to remove xenoreactive NAb. A pig-to-dog renal transplantation model was used for discordant combination xenografting. The experimental animals were divided into 4 groups: group 1, control; group 2, recipients splenectomized prior to renal xenografting; group 3, splenectomy along with ex vivo spleen xenoreactive NAb absorption; and group 4, splenectomy along with ex vivo spleen and kidney xenoreactive NAb absorption. After the pretransplant treat...
Subjects
free text keywords: Organ Absorption, Renal Xenotransplantation, 490, Hyperacute Rejection
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Research . Article . 1996

Ex Vivo Spleen and Kidney Absorption of Xenoreactive Natural Antibodies Decreases Severity of Hyperacute Rejection in Pig-to-dog Renal Xenotransplantation

Nitta, Kohsaku;