Imputation-Based Population Genetics Analysis of Plasmodium falciparum Malaria Parasites

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Samad, Hanif; Coll, Francesc; Preston, Mark D.; Ocholla, Harold; Fairhurst, Rick M.; Clark, Taane G.;
  • Publisher: Public Library of Science
  • Journal: PLoS Genetics,volume 11,issue 4 (issn: 1553-7390, eissn: 1553-7404)
  • Related identifiers: pmc: PMC4415759, doi: 10.1371/journal.pgen.1005131
  • Subject: QH426-470 | Genetics | Research Article
    mesheuropmc: parasitic diseases

Whole-genome sequencing technologies are being increasingly applied to Plasmodium falciparum clinical isolates to identify genetic determinants of malaria pathogenesis. However, genome-wide discovery methods, such as haplotype scans for signatures of natural selection, ... View more