Defective Glycinergic Synaptic Transmission in Zebrafish Motility Mutants

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Hirata, Hiromi ; Carta, Eloisa ; Yamanaka, Iori ; Harvey, Robert J. ; Kuwada, John Y. (2010)
  • Publisher: Frontiers Research Foundation
  • Journal: Frontiers in Molecular Neuroscience, volume 2 (issn: 1662-5099, eissn: 1662-5099)
  • Related identifiers: doi: 10.3389/neuro.02.026.2009, doi: 10.3389/neuro.02.026.2009/full, pmc: PMC2813725
  • Subject: Review Article | glycine, synapse, receptor, transporter, zebrafish, behavior, motility | Neurosciences. Biological psychiatry. Neuropsychiatry | Neuroscience | RC321-571 | Locomotion | synapse | receptor | glycine | transporter | motility | zebrafish | behavior

Glycine is a major inhibitory neurotransmitter in the spinal cord and brainstem. Recently, in vivo analysis of glycinergic synaptic transmission has been pursued in zebrafish using molecular genetics. An ENU mutagenesis screen identified two behavioral mutants that are ... View more
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