Analysis of Horse Myostatin Gene and Identification of Single Nucleotide Polymorphisms in Breeds of Different Morphological Types

Article English OPEN
Dall’Olio S.; Fontanesi L.; Nanni Costa L.; Tassinari M.; Minieri L.; Falaschini A.;

Myostatin, encoded by MSTN gene, is one negative modulator of muscle mass. We characterized horse (Equus caballus) MSTN gene and identified and analysed single nucleotide polymorphisms (SNPs) in breeds of different morphological types. Sequencing of coding, untranslated... View more
  • References (39)
    39 references, page 1 of 4

    McPherron, A. C., Lawler, A. M., Lee, S.-J.. Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member. Nature. 1997; 387 (6628): 83-90

    McPherron, A. C., Lee, S.-J.. Double muscling in cattle due to mutations in the myostatin gene. Proceedings of the National Academy of Sciences of the United States of America. 1997; 94 (23): 12457-12461

    Joulia-Ekaza, D., Cabello, G.. Myostatin regulation of muscle development: molecular basis, natural mutations, physiopathological aspects. Experimental Cell Research. 2006; 312 (13): 2401-2414

    Gonzalez-Cadavid, N. F., Taylor, W. E., Yarasheski, K., Sinha-Hikim, I., Ma, K., Ezzat, S., Shen, R., Lalani, R., Asa, S., Mamita, M., Nair, G., Arver, S., Bhasin, S.. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proceedings of the National Academy of Sciences of the United States of America. 1998; 95 (25): 14938-14943

    Stratil, A., Kopecny, M.. Genomic organization, sequence and polymorphism of the porcine myostatin (GDF8; MSTN) gene. Animal Genetics. 1999; 30 (6): 468-469

    Jeanplong, F., Sharma, M., Somers, W. G., Bass, J. J., Kambadur, R.. Genomic organization and neonatal expression of the bovine myostatin gene. Molecular and Cellular Biochemistry. 2001; 220 (1-2): 31-37

    Du, R., Chen, Y.-F., An, X.-R., Yang, X.-Y., Ma, Y., Zhang, L., Yuan, X.-L., Chen, L.-M., Qin, J.. Cloning and sequence analysis of myostatin promoter in sheep. DNA Sequence. 2005; 16 (6): 412-417

    Stinckens, A., Luyten, T., Bijttebier, J., Van Den Maagdenberg, K., Dieltiens, D., Janssens, S., De Smet, S., Georges, M., Buys, N.. Characterization of the complete porcine MSTN gene and expression levels in pig breeds differing in muscularity. Animal Genetics. 2008; 39 (6): 586-596

    Schuelke, M., Wagner, K. R., Stolz, L. E., Hübner, C., Riebel, T., Kömen, W., Braun, T., Tobin, J. F., Lee, S.-J.. Myostatin mutation associated with gross muscle hypertrophy in a child. New England Journal of Medicine. 2004; 350 (26): 2682-2688

    Kambadur, R., Sharma, M., Smith, T. P. L., Bass, J. J.. Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle. Genome Research. 1997; 7 (9): 910-916

  • Related Research Results (2)
  • Related Organizations (1)
  • Metrics