Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells

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Mühlgassner, Gerhard; Bartel, Caroline; Schmid, Wolfgang F.; Jakupec, Michael A.; Arion, Vladimir B.; Keppler, Bernhard K.;
(2012)
  • Publisher: Elsevier
  • Journal: Journal of Inorganic Biochemistry,volume 116,issue 5,pages180-187 (issn: 0162-0134, eissn: 1873-3344)
  • Related identifiers: doi: 10.1016/j.jinorgbio.2012.06.003, pmc: PMC3492762
  • Subject: Inorganic Chemistry | Indolobenzazepines | Ruthenium | Cyclin-dependent kinases | Biochemistry | Osmium | Paullones | Article | Arene complexes

In an attempt to combine the ability of indolobenzazepines (paullones) to inhibit cyclin-dependent kinases (Cdks) and that of platinum-group metal ions to interact with proteins and DNA, ruthenium(II) and osmium(II) arene complexes with paullones were prepared, expectin... View more
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