Inhibition of GABAergic Neurotransmission by HIV-1 Tat and Opioid Treatment in the Striatum Involves μ-Opioid Receptors

Article English OPEN
Xu, Changqing; Fitting, Sylvia;
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Neuroscience,volume 10 (issn: 1662-453X, eissn: 1662-453X)
  • Related identifiers: doi: 10.3389/fnins.2016.00497, doi: 10.3389/fnins.2016.00497/full, pmc: PMC5099255
  • Subject: HIV-1 Tat | striatum | Neurosciences. Biological psychiatry. Neuropsychiatry | Neuroscience | RC321-571 | GABA neurotransmission | Original Research | µ-opioid receptor | CTAP | μ-opioid receptor | morphine

Due to combined antiretroviral therapy (cART), human immunodeficiency virus type 1 (HIV-1) is considered a chronic disease with high prevalence of mild forms of neurocognitive impairments, also referred to as HIV-associated neurocognitive disorders (HAND). Although opia... View more