Grass Carp Laboratory of Genetics and Physiology 2 Serves As a Negative Regulator in Retinoic Acid-Inducible Gene I- and Melanoma Differentiation-Associated Gene 5-Mediated Antiviral Signaling in Resting State and Early Stage of Grass Carp Reovirus Infection
Rao, Youliang; Wan, Quanyuan; Yang, Chunrong; Su, Jianguo;
Publisher: Frontiers Media S.A.
Journal: Frontiers in Immunology,volume 8 (issn: 1664-3224, eissn: 1664-3224)
Subject: grass carp (Ctenopharyngodon idella) | grass carp reovirus | innate immunity | interferon regulatory factor 3 | Original Research | laboratory of genetics and physiology 2 | IRF7 | Immunology | RLRs
Laboratory of genetics and physiology 2 (LGP2) is a key component of RIG-I-like receptors (RLRs). However, the lack of the caspase recruitment domains (CARDs) results in its controversial functional performance as a negative or positive regulator in antiviral responses.... View more