Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Article, Other literature type English OPEN
Pardi, Norbert ; Tuyishime, Steven ; Muramatsu, Hiromi ; Kariko, Katalin ; Mui, Barbara L. ; Tam, Ying K. ; Madden, Thomas D. ; Hope, Michael J. ; Weissman, Drew (2015)

In recent years, in vitro transcribed messenger RNA (mRNA) has emerged as a potential therapeutic platform. To fulfill its promise, effective delivery of mRNA to specific cell types and tissues needs to be achieved. Lipid nanoparticles (LNPs) are efficient carriers for ... View more
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