Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease.

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Franklin R Toapanta; Paula J Bernal; Stephanie Fresnay; Thomas C Darton; Claire Jones; Claire S Waddington; Christoph J Blohmke; Gordon Dougan; Brian Angus; Myron M Levine; Andrew J Pollard; Marcelo B Sztein;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Neglected Tropical Diseases,volume 9,issue 6 (issn: 1935-2727, eissn: 1935-2735)
  • Related identifiers: pmc: PMC4465829, doi: 10.1371/journal.pntd.0003837
  • Subject: RC955-962 | Research Article | RA1-1270 | Public aspects of medicine | Arctic medicine. Tropical medicine

A new human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently developed. In this model, ingestion of 104 CFU of Salmonella resulted in 65% of subjects developing typhoid fever (referred here as typhoid diagnosis -TD-) 5-10 days post-challenge.... View more
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