Low-density Lipoprotein Receptor-related Protein-1 (LRP1) Mediates Autophagy and Apoptosis Caused by Helicobacter pylori VacA

Article, Other literature type English OPEN
Yahiro, Kinnosuke; Satoh, Mamoru; Nakano, Masayuki; Hisatsune, Junzo; Isomoto, Hajime; Sap, Jan; Suzuki, Hidekazu; Nomura, Fumio; Noda, Masatoshi; Moss, Joel; Hirayama, Toshiya;
  • Publisher: American Society for Biochemistry and Molecular Biology Inc.
  • Journal: Journal of Biological Chemistry,volume 287,issue 37,pages31,104-31,115 (issn: 0021-9258)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3438942, doi: 10.1074/jbc.M112.387498
  • Subject: Helicobacter pylori | Autophagy | Cytotoxins | Microbiology | Mitochondrial damage | Cell surface receptors | Autophagosomes | Caspase inhibitors | Gastric epithelial cells | Low density lipoproteins | Cellular damage
    mesheuropmc: bacteria | bacterial infections and mycoses | digestive system diseases

In Helicobacter pylori infection, vacuolating cytotoxin (VacA)-induced mitochondrial damage leading to apoptosis is believed to be a major cause of cell death. It has also been proposed that VacA-induced autophagy serves as a host mechanism to limit toxin-induced cellul... View more
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