publication . Other literature type . Article . 2011

Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism

Alan O. Perantoni; Honghe Wang; Luis Rodríguez; Nirmala Sharma; Terry P. Yamaguchi; Nadya I. Tarasova; Rieko Ajima; Yili Yang; Shunsuke Tanigawa;
Open Access English
  • Published: 01 Apr 2011
Abstract Wnt4 and β-catenin are both required for nephrogenesis, but studies using TCF-reporter mice suggest that canonical Wnt signaling is not activated in metanephric mesenchyme (MM) during its conversion to the epithelia of the nephron. To better define the role of Wnt signaling, we treated rat metanephric mesenchymal progenitors directly with recombinant Wnt proteins. These studies revealed that Wnt4 protein, which is required for nephron formation, induces tubule formation and differentiation markers Lim1 and E-cadherin in MM cells, but does not activate a TCF reporter or up regulate expression of canonical Wnt target gene Axin-2 and has little effect on t...
Medical Subject Headings: animal structures
free text keywords: Article, Developmental Biology, Cell Biology, Molecular Biology, Wnt, β-Catenin, Kidney, Tubulogenesis, Peptidomimetic, Cellular differentiation, LRP6, Mesenchymal–epithelial transition, Biology, WNT4, Wnt signaling pathway, Ca2+/calmodulin-dependent protein kinase, Beta-catenin, biology.protein, LRP5
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