Effects of chronic morphine and morphine withdrawal on gene expression in rat peripheral blood mononuclear cells.
Desjardins , Stephane; Belkai , Emilie; Crete , Dominique; Cordonnier , Laurie; Scherrmann , Jean-Michel; Noble , Florence; Marie-Claire , Cynthia;
- Publisher: HAL CCSD
- Subject: MESH: Animals | MESH: Male | MESH: Receptors, Opioid, delta | MESH: Rats | MESH: RNA, Messenger | MESH: Gene Expression Regulation | MESH: Substance Withdrawal Syndrome | MESH: Narcotics | MESH: Time Factors | [ SDV.BBM.GTP ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] | MESH: Rats, Sprague-Dawley | MESH: Behavior, Animal | MESH: Morphine | [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] | MESH: Leukocytes, Mononuclear | MESH: Social Environment | MESH: Analysis of Variance | MESH: Transcription, Genetic | MESH: Oligonucleotide Array Sequence Analysis | MESH: Protein Precursors | MESH: Gene Expression Profiling
International audience; Chronic morphine treatment alters gene expression in brain structures. There are increasing evidences showing a correlation, in gene expression modulation, between blood cells and brain in psychological troubles. To test whether gene expression r... View more