Embryonic Lethality of Mitochondrial Pyruvate Carrier 1 Deficient Mouse Can Be Rescued by a Ketogenic Diet

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Benoît Vanderperre; Sébastien Herzig; Petra Krznar; Manuel Hörl; Zeinab Ammar; Sylvie Montessuit; Sandra Pierredon; Nicola Zamboni; Jean-Claude Martinou;
(2016)
  • Publisher: Public Library of Science (PLoS)
  • Journal: volume 12,issue 5issn: 1553-7390, eissn: 1553-7404
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4866774, doi: 10.3929/ethz-b-000117646, doi: 10.1371/journal.pgen.1006056
  • Subject: Energy-Producing Organelles | Molecular Biology | Research Article | Ketones | Chemical Compounds | QH426-470 | Genetics | Physical Sciences | Acids | Cell Labeling | Bioenergetics | Embryos | Metabolomics | Molecular Biology Techniques | Metabolic Labeling | Diet | Embryology | Chemistry | Biology and Life Sciences | Developmental Biology | Mitochondria | Research and Analysis Methods | Pyruvate | Metabolites | Nutrition | Citric Acid Cycle | Cell Biology | Metabolic Processes | Cellular Structures and Organelles | Biochemistry | Metabolism | Medicine and Health Sciences
    mesheuropmc: immune system diseases

Mitochondrial import of pyruvate by the mitochondrial pyruvate carrier (MPC) is a central step which links cytosolic and mitochondrial intermediary metabolism. To investigate the role of the MPC in mammalian physiology and development, we generated a mouse strain with c... View more
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