FabQ, a Dual-Function Dehydratase/Isomerase, Circumvents the Last Step of the Classical Fatty Acid Synthesis Cycle

Article, Other literature type English OPEN
Bi, Hongkai ; Wang, Haihong ; Cronan, John E. (2013)
  • Publisher: Elsevier BV
  • Journal: Chemistry & Biology, volume 20, issue 9, pages 1,157-1,167 (issn: 1074-5521)
  • Related identifiers: pmc: PMC4562794, doi: 10.1016/j.chembiol.2013.07.007
  • Subject: Molecular Biology | Drug Discovery | Biochemistry | Pharmacology | Molecular Medicine | Clinical Biochemistry | Article

In the classical anaerobic pathway of unsaturated fatty acid biosynthesis, that of Escherichia coli, the double bond is introduced into the growing acyl chain by the FabA dehydratase/isomerase. Another dehydratase, FabZ, functions in the chain elongation cycle. In contr... View more
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