Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation

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Alfieri, Roberta ; Barberis, Matteo ; Chiaradonna, Ferdinando ; Gaglio, Daniela ; Milanesi, Luciano ; Vanoni, Marco ; Klipp, Edda ; Alberghina, Lilia (2009)
  • Publisher: Springer Nature
  • Journal: BMC Bioinformatics, volume 10, issue Suppl 12, pages S16-S16 (issn: 1471-2105, eissn: 1471-2105)
  • Related identifiers: pmc: PMC2762065, doi: 10.1186/1471-2105-10-s12-s16
  • Subject: Molecular Biology | Biochemistry | Computer Science Applications | Research

Background The cell cycle is a complex process that allows eukaryotic cells to replicate chromosomal DNA and partition it into two daughter cells. A relevant regulatory step is in the G0/G1 phase, a point called the restriction (R) point where intracellular and extracel... View more
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