Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation

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Alfieri, Roberta; Barberis, Matteo; Chiaradonna, Ferdinando; Gaglio, Daniela; Milanesi, Luciano; Vanoni, Marco; Klipp, Edda; Alberghina, Lilia;

Background The cell cycle is a complex process that allows eukaryotic cells to replicate chromosomal DNA and partition it into two daughter cells. A relevant regulatory step is in the G0/G1 phase, a point called the restriction (R) point where intracellular and extracel... View more
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