Ovarian Cyst Fluid of Serous Ovarian Tumors Contains Large Quantities of the Brain Amino Acid N-acetylaspartate

Article OPEN
Kolwijck, E. ; Wevers, R.A. ; Engelke, U.F. ; Woudenberg, J. ; Bulten, J. ; Blom, H.J. ; Massuger, L.F.A.G. (2010)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 5, issue 4 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC2858663, doi: 10.1371/journal.pone.0010293
  • Subject: Q | R | Research Article | Biochemistry | Women's Health | Chemistry/Biochemistry | Science | Medicine
    mesheuropmc: nervous system diseases | nervous system | immune system diseases | mental disorders

BACKGROUND: In humans, N-acetyl L-aspartate (NAA) has not been detected in other tissues than the brain. The physiological function of NAA is yet undefined. Recently, it has been suggested that NAA may function as a molecular water pump, responsible for the removal of l... View more
  • References (23)
    23 references, page 1 of 3

    1. Baslow M H (2003) N -acetylaspartate in the vertebrate brain: m etabolism and function. N eurochem Res 28: 941-953.

    2. M offett J R , Ross B, A run P, M adhavarao CN , N am boodiri A M (2007) NA cetylaspartate in the CN S: from neurodiagnostics to neurobiology. Prog N eurobiol 81: 89-131.

    3. G eorge RL, H u ang W , N aggar H A , Sm ith SB, G anapathy V (2004) T ransport o f N -acetylaspartate via m urine sodium /dicarboxylate cotransporter N aD C 3 and expression o f this transporter and aspartoacylase II in ocular tissues in mouse. Biochim Biophys A cta 1690: 63-69.

    4. Burlina A P, Schm itt B, Engelke U , W evers RA , Burlina AB, et al. (2006) H ypoacetylaspartia: clinical and biochem ical follow-up o f a patient. Adv Exp M ed Biol 576: 283-287.

    5. Baslow M H (2002) Evidence supporting a role for N -acetyl-L-aspartate as a m olecular w ater pu m p in m yelinated neurons in the central nervous system. An analytical review. N eurochem In t 40: 295-300.

    6. Baslow M H (1999) T h e existence of m olecular w ater pum ps in the nervous system: a review of the evidence. N eurochem In t 34: 77-90.

    7. Jakobs C , ten Brink H J, Langelaar SA, Zee T , Stellaard F, et al. (1991) Stable isotope dilution analysis of N -acetylaspartic acid in C SF, blood, urine and am niotic fluid: accurate postnatal diagnosis an d the potential for prenatal diagnosis o f C an av an disease. J In herit M etab Dis 14: 653-660.

    8. Burlina A P, F errari V , Facci L, Skaper SD, Burlina AB (1997) M ast cells contain large quantities of secretagogue-sensitive N -acetylaspartate. J N eurochem 69: 1314-1317.

    9. Baslow M H , Y am ada S (1997) Identification o f N -acetylaspartate in the lens of the vertebrate eye: a new m odel for the investigation o f the function o f Nacetylated am ino acids in vertebrates. Exp Eye Res 64: 283-286.

    10. Boss EA , M oolenaar SH , M assuger LF, Boonstra H , Engelke U F, et al. (2000) H igh-resolution proto n nuclear m agnetic resonance spectroscopy o f ovarian cyst fluid. N M R Biom ed 13: 297-305.

  • Related Research Results (3)
  • Metrics
    No metrics available
Share - Bookmark