Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

Article, Other literature type English OPEN
Ryan, Scott D. ; Dolatabadi, Nima ; Chan, Shing Fai ; Zhang, Xiaofei ; Akhtar, Mohd Waseem ; Parker, James ; Soldner, Frank ; Sunico, Carmen R. ; Nagar, Saumya ; Talantova, Maria ; Lee, Brian ; Lopez, Kevin ; Nutter, Anthony ; Shan, Bing ; Molokanova, Elena ; Zhang, Yaoyang ; Han, Xuemei ; Nakamura, Tomohiro ; Masliah, Eliezer ; Yates, John R. ; Nakanishi, Nobuki ; Andreyev, Aleksander Y. ; Okamoto, Shu-ichi ; Jaenisch, Rudolf ; Ambasudhan, Rajesh ; Lipton, Stuart A. (2013)

Parkinson’s disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). An association has been reported between PD and exposure to mitochondrial toxins, including environmental pesticides paraquat, maneb, and rote... View more
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