Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat Cultures

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Mauricio Vergara; Julio Berrios; Irene Martínez; Alvaro Díaz-Barrera; Cristian Acevedo; Juan G Reyes; Ramon Gonzalez; Claudia Altamirano;

Background Chinese hamster ovary (CHO) cells are the main host for producing recombinant proteins with human therapeutic applications mainly because of their capability to perform proper folding and glycosylation processes. In addition, mild hypothermia is one of the ma... View more
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