Analysis of the prion protein gene in multiple system atrophy

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Chelban, Viorica; Manole, Andreea; Pihlstrøm, Lasse; Schottlaender, Lucia; Efthymiou, Stephanie; OConnor, Emer; Meissner, Wassilios G.; Holton, Janice L.; Houlden, Henry;
  • Publisher: Elsevier BV
  • Journal: Neurobiology of Aging, volume 49, pages 216,000,000,000,000,000-216,000,000,000,000,000,000 (issn: 0197-4580, eissn: 1558-1497)
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  • Identifiers: doi: 10.1016/j.neurobiolaging.2016.09.021, pmc: PMC5156473
  • Subject: Genetic Report Abstract | Neuroscience(all) | Sporadic Creutzfeld-Jakob disease | confidence intervals, CI | Ageing | Prion disease | odds ratio, OR | sporadic Creutzfeld-Jakob disease, sCJD | Developmental Biology | Brief Communication | Multiple system atrophy | α-synuclein, α-syn | prion protein, PrP | Geriatrics and Gerontology | PRNP | Clinical Neurology | multiple system atrophy, MSA | cytoplasmic inclusions, GCIs | Prion protein
    mesheuropmc: mental disorders | nervous system diseases | animal diseases

Neurodegenerative diseases are a very diverse group of disorders but they share some common mechanisms such as abnormally misfolded proteins with prion-like propagation and aggregation. Creutzfeldt-Jakob disease (CJD) is the most prevalent prion disease in humans. In th... View more
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