Extensive alternative splicing of the repressor element silencing transcription factor linked to cancer.

Article English OPEN
Chen, Guo-lin; Miller, Gregory Michael;
(2013)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 8,issue 4 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0062217, pmc: PMC3628349
  • Subject: Computational Biology | Molecular cell biology | Research Article | Cancer Risk Factors | RNA processing | Epigenetics | Oncology | Epidemiology | Genetics | Cancer Genetics | Genetic Causes of Cancer | Physics | Gene Splicing | Biophysics | Molecular Genetics | Biology | RNA | Medicine | Nucleic acids | Basic Cancer Research | Biomarker Epidemiology | Q | R | Gene Regulation | Biochemistry | Science | Gene expression

The repressor element silencing transcription factor (REST) is a coordinate transcriptional and epigenetic regulator which functions as a tumor suppressor or an oncogene depending on cellular context, and a truncated splice variant REST4 has been linked to various types... View more