The Caenorhabditis elegans interneuron ALA is (also) a high-threshold mechanosensor

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Sanders, Jarred; Nagy, Stanislav; Fetterman, Graham; Wright, Charles; Treinin, Millet; Biron, David;

Background To survive dynamic environments, it is essential for all animals to appropriately modulate their behavior in response to various stimulus intensities. For instance, the nematode Caenorhabditis elegans suppresses the rate of egg-laying in response to intense m... View more
  • References (79)
    79 references, page 1 of 8

    1. Bromm B, Treede RD: Withdrawal reflex, skin resistance reaction and pain ratings due to electrical stimuli in man. Pain 1980, 9:339-354.

    2. Wittenburg N, Baumeister R: Thermal avoidance in Caenorhabditis elegans: an approach to the study of nociception. Proc Natl Acad Sci USA 1999, 96:10477-10482.

    3. Basbaum AI, Bautista DM, Scherrer G, Julius D: Cellular and molecular mechanisms of pain. Cell 2009, 139:267-284.

    4. Gold MS, Gebhart GF: Nociceptor sensitization in pain pathogenesis. Nat Med 2010, 16:1248-1257.

    5. Mohammadi A, Byrne Rodgers J, Kotera I, Ryu WS: Behavioral response of Caenorhabditis elegans to localized thermal stimuli. BMC Neurosci 2013, 14:66.

    6. Chatzigeorgiou M, Yoo S, Watson JD, Lee W-H, Spencer WC, Kindt KS, Hwang SW, Miller DM, Treinin M, Driscoll M, Schafer WR: Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Nat Neurosci 2010, 13:861-868.

    7. Smith ESJ, Lewin GR: Nociceptors: a phylogenetic view. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2009, 195:1089-1106.

    8. Albeg A, Smith CJ, Chatzigeorgiou M, Feitelson DG, Hall DH, Schafer WR, Miller DM, Treinin M: C. elegans multi-dendritic sensory neurons: morphology and function. Mol Cell Neurosci 2011, 46:308-317.

    9. Way JC, Chalfie M: mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans. Cell 1988, 54:5-16.

    10. Hall DH, Treinin M: How does morphology relate to function in sensory arbors? Trends Neurosci 2011, 34:443-451.

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